Use of S1P Receptor Modulator – application number: 20140011884. Applicants: Novartis AG Type: Application Filed: DecemIssued: August 21, 2014.ģ. KUHN, Tomoya MATSUMOTO, Anis Khusro MIR, Anna Svenja SCHUBART. Inventors: Yves-Alain BARDE, Graeme BILBE, Ruben Deogracias, Rainer R. Abstract: Use of an S1P receptor modulator in the treatment or prevention of a disease or condition dependent on brain-derived neurotrophic factor (BDNF) expression. Use of S1P Receptor Modulator – application number: 20140235610. Applicant: RENEURON LIMITED Type: Application. Inventors: Randolph CORTELING, Rubén DEOGRACIAS.
Abstract: This invention relates to genetic engineering, in particular to an insertion site for a transgene, cells comprising a transgene or other modification at that insertion site, vectors for targeting that insertion site, and methods for creating transgenic cells by insertion or other modification at that site. Genetic modification Site – application number: PCT/GB2020/051906. Voces Internas durante el desarrollo de las neuronas GABAérgicas / Inner Voices of the Development of GABAergic neurons (InVoDeGa).
Rauskolb S, Zagrebelsky M, Dreznjak A, Deogracias R, Matsumoto T, Wiese S, Erne B, Sendtner M, Schaeren-Wiemers, Korte M and Barde Y-A. Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth.Vidaurre O-G#, Gascón S#, Deogracias R, Sobrado M, Cuadrado E, Montaner J, Rodríguez-Peña A, and M. Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity.Dieni S, Matsumoto T, Dekkers M, Rauskolb S, Ionescu M, Deogracias R, Gundelfinger E-D, Kojima M, Nestel S, Frotscher M, Barde Y-A. BDNF and its pro-peptide are stored in presynaptic large dense core vesicles in brain neurons.C, Boege F, Lyu Y-L, Peters A, Barde Y-A, Schübeler D. Tiwari W, Burger L#, Nikoletopoulou V#, Deogracias R, Wirbelauer C, Murr R, Terranova R, Mielke. Topoisomerase IIβ binding to promoters in postmitotic cells modulates gene activity and regulates neuronal survival.Deogracias R*, Yazdani M*, Guy J, Poot RA, Bird A, Barde Y-A. Disease modeling using embryonic stem cells: MeCP2 regulates nuclear size and RNA synthesis in neurons.Deogracias R*, Bischoff V, Poirier F, Barde Y-A. Seizure-induced neuronal death is suppressed in the absence of the endogenous lectin Galectin1.Deogracias R*, Yazdani M*, Dekkers MP, Guy J, Ionescu MC, Vogt KE, Barde YA. Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome.Favuzzi E, Deogracias R*, Marques-Smith A*, Winterflood CM, Sánchez-Aguilera A, Mantoan L, Maeso P, Fernandes C, Ewers H, Rico B. Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.The Microtubule Regulator NEK7 Coordinates the Wiring of Cortical Parvalbumin Interneurons.Deogracias R*, Favuzzi E*, Marques-Smith A, Maeso P, Jezequel J, Exposito-Alonso D, Balia M, Kroon T, Hinojosa AJ, Maraver EF, Rico B. Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits.
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